ATIM-24. DOSE FINDING AND DOSE EXPANSION TRIAL OF D2C7 IMMUNOTOXIN (D2C7-IT) ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOR RECURRENT MALIGNANT GLIOMA (MG)

BACKGROUND: D2C7-IT is a recombinant immunotoxin comprised of a dual-specific antibody fragment targeting EGFRwt and EGFRvIII and a genetically engineered form of the Pseudomonas exotoxin, PE38-KDEL. We report results of a phase 1 trial, with dose expansion at the selected phase 2 dose, evaluating D...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Desjardins, Annick, Randazzo, Dina, Chandramohan, Vidya, Peters, Katherine, Johnson, Margaret, Threatt, Stevie, Bullock, Chevelle, Jackman, Jenny, Healy, Patrick, Lipp, Eric, Sampson, John, Friedman, Allan, Friedman, Henry, Ashley, David, Bigner, Darell
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Adult Clinical Trials–Immunologic
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847249/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.023
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