Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats

The trinucleotide repeat expansion disorders (TREDs) constitute of a group of >40 hereditary neurodegenerative human diseases associated with abnormal expansion of repeated sequences, such as CAG repeats. The pathogenic factor is a transcribed RNA or protein whose function in the cell is compromi...

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Foilsithe in:Nucleic Acids Res
Main Authors: Mukherjee, Sanjukta, Błaszczyk, Leszek, Rypniewski, Wojciech, Falschlunger, Christoph, Micura, Ronald, Murata, Asako, Dohno, Chikara, Nakatani, Kazuhiko, Kiliszek, Agnieszka
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2019
Ábhair:
Structural Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847237/
https://ncbi.nlm.nih.gov/pubmed/31566242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz832
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