CBMT-32. EGFR SUPPRESSES p53 FUNCTION THROUGH DNA-PKcs BINDING TO p53: NOVEL CROSSTALK BETWEEN EGFR AND TP53 IN GLIOBLASTOMA

Comprehensive analysis of the TCGA Glioblastoma database has identified 3 prognostically relevant subgroups (Proneural, Classical and Mesenchymal). Interestingly, it has also revealed a near mutual exclusivity of EGFR amplification and TP53 mutations. There are only a few tumors with both amplified...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Ding, Jie, Li, Xiaolong, Zhang, Chen, Gao, Feng, Wu, Shaofang, Wasylishen, Amanda, Baggerly, Keith, Lozano, Guillermina, Koul, Dimpy, Yung, Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Cell Biology and Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847097/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.154
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