CBIO-02. AMPLIFIED EGFR DRIVES TUMORIGENESIS IN TP53 WILD TYPE GLIOBLASTOMA THROUGH INHIBITION OF p53 FUNCTION BY DNA-PK/p53 BINDING

Epidermal growth factor receptor (EGFR) amplification/mutation and TP53 mutation are two most frequent genetic events that differentiate molecular subtypes of Glioblastoma. An extensive analysis of the Glioblastoma TCGA database showed a near exclusivity between p53 mutation and EGFR amplification i...

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Pubblicato in:Neuro Oncol
Autori principali: Ding, Jie, Li, Xiaolong, Wasylishen, Amanda, Gao, Feng, Zhao, Yang, Baggerly, Keith, Lozano, Guillermina, Koul, Dimpy, Yung, W K Alfred
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691886/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.125
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