CSIG-23. NOTCH ACTIVATION INDUCED BY HSV-1 ENCODED miRNA-H16 SENSITIZES oHSV-TREATED TUMORS TO NOTCH INHIBITOR

INTRODUCTION: Glioblastomas (GBMs) are resistant to traditional therapies, and new treatment is urgently needed. NOTCH signaling is highly activated in glioma and activated NOTCH signaling is associated with increased tumor growth and therapeutic resistance. Effect of oncolytic virus therapy on NOTC...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Otani, Yoshihiro, Young Yoo, Ji, Chao, Samantha, Liu, Joseph, Cristina Jaime-Ramirez, Alena, Jin Lee, Tae, Hurwitz, Brian, Yan, Yuanqing, Dai, Hongsheng, Glorioso, Joseph C, Caligiuri, Michael A, Yu, Jianhua, Kaur, Balveen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Cell Signaling and Signaling Pathways
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846962/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.193
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