CSIG-23. NOTCH ACTIVATION INDUCED BY HSV-1 ENCODED miRNA-H16 SENSITIZES oHSV-TREATED TUMORS TO NOTCH INHIBITOR

INTRODUCTION: Glioblastomas (GBMs) are resistant to traditional therapies, and new treatment is urgently needed. NOTCH signaling is highly activated in glioma and activated NOTCH signaling is associated with increased tumor growth and therapeutic resistance. Effect of oncolytic virus therapy on NOTC...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Otani, Yoshihiro, Young Yoo, Ji, Chao, Samantha, Liu, Joseph, Cristina Jaime-Ramirez, Alena, Jin Lee, Tae, Hurwitz, Brian, Yan, Yuanqing, Dai, Hongsheng, Glorioso, Joseph C, Caligiuri, Michael A, Yu, Jianhua, Kaur, Balveen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Cell Signaling and Signaling Pathways
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846962/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.193
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