Dynamics of the DEAD-box ATPase Prp5 RecA-like domains provide a conformational switch during spliceosome assembly

The DEAD-box family of proteins are ATP-dependent, RNA-binding proteins implicated in many aspects of RNA metabolism. Pre-mRNA splicing in eukaryotes requires three DEAD-box ATPases (Prp5, Prp28 and Sub2), the molecular mechanisms of which are poorly understood. Here, we use single molecule FRET (sm...

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Publicat a:Nucleic Acids Res
Autors principals: Beier, David H, Carrocci, Tucker J, van der Feltz, Clarisse, Tretbar, U Sandy, Paulson, Joshua C, Grabowski, Nikolai, Hoskins, Aaron A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
RNA and RNA-protein complexes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846040/
https://ncbi.nlm.nih.gov/pubmed/31712821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz765
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