SCIDOT-14. ENHANCING BRAIN RETENTION OF A KIF11 INHIBITOR SIGNIFICANTLY IMPROVES ITS EFFICACY IN A MOUSE MODEL OF GLIOBLASTOMA

Glioblastoma, the most common and lethal of brain tumors, is both highly invasive and proliferative. This allows tumor cells to infiltrate into regions of the brain with an intact blood brain barrier and be protected from effective therapeutics. Thus, an ideal glioblastoma therapy needs to target ce...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Gampa, Gautham, Kenchappa, Rajappa, Mohammad, Afroz, Parrish, Karen, Kim, Minjee, Sarkaria, Jann, Rosenfeld, Steven, Elmquist, William
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Abstracts from the 3rd Sno-Scidot Joint Conference on Therapeutic Delivery to the CNS
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6845720/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1150
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