Limited role of kininogen in the host response during gram-negative pneumonia-derived sepsis

High-molecular-weight kininogen (HK), together with factor XI, factor XII and prekallikrein, is part of the contact system that has proinflammatory, prothrombotic, and vasoactive properties. We hypothesized that HK plays a role in the host response during pneumonia-derived sepsis. To this end mice w...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Ding, Chao, van ’t Veer, Cornelis, Roelofs, Joris J. T. H., Shukla, Meenal, McCrae, Keith R., Revenko, Alexey S., Crosby, Jeff, van der Poll, Tom
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842874/
https://ncbi.nlm.nih.gov/pubmed/29122754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00288.2017
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