A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia-Derived Gram-Negative Sepsis (Melioidosis)

BACKGROUND: During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (...

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Detalhes bibliográficos
Main Authors: Kager, Liesbeth M., Wiersinga, W. Joost, Roelofs, Joris J. T. H., de Boer, Onno J., Weiler, Hartmut, van 't Veer, Cornelis, van der Poll, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998929/
https://ncbi.nlm.nih.gov/pubmed/24762740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002819
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