Overexpression of activated protein C hampers bacterial dissemination during pneumococcal pneumonia

BACKGROUND: During pneumonia, inflammation and coagulation are activated as part of anti-bacterial host defense. Activated protein C (APC) has anticoagulant and anti-inflammatory properties and until recently was a registered drug for the treatment of severe sepsis. Streptococcus (S.) pneumoniae is...

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Detalhes bibliográficos
Publicado no:BMC Infect Dis
Main Authors: de Boer, Johannes Daan, Kager, Liesbeth M, Roelofs, Joris JTH, Meijers, Joost CM, de Boer, Onno J, Weiler, Hartmut, Isermann, Berend, van ’t Veer, Cornelis, van der Poll, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4228088/
https://ncbi.nlm.nih.gov/pubmed/25366058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-014-0559-3
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