Thrombocytopenia impairs host defense in gram-negative pneumonia–derived sepsis in mice

Thrombocytopenia is a common finding in sepsis and associated with a worse outcome. We used a mouse model of pneumonia-derived sepsis caused by the human pathogen Klebsiella pneumoniae to study the role of platelets in host response to sepsis. Platelet counts (PCs) were reduced to less than a median...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: de Stoppelaar, Sacha F., van ’t Veer, Cornelis, Claushuis, Theodora A. M., Albersen, Bregje J. A., Roelofs, Joris J. T. H., van der Poll, Tom
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2014
Assuntos:
Platelets and Thrombopoiesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263985/
https://ncbi.nlm.nih.gov/pubmed/25301709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-573915
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