Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model

High-molecular-weight kininogen is an important substrate of the kallikrein-kinin system. Activation of this system has been associated with aggravation of hallmark features in asthma. We aimed to determine the role of kininogen in enhanced pause (Penh) measurements and lung inflammation in a house...

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Publicado en:Am J Physiol Lung Cell Mol Physiol
Main Authors: Yang, Jack, van ’t Veer, Cornelis, Roelofs, Joris J. T. H., van Heijst, Jeroen W. J., de Vos, Alex F., McCrae, Keith R., Revenko, Alexey S., Crosby, Jeff, van der Poll, Tom
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859420/
https://ncbi.nlm.nih.gov/pubmed/30358441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00162.2018
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