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Deletions associated with stabilization of the Top1 cleavage complex in yeast are products of the nonhomologous end-joining pathway
Topoisomerase I (Top1) resolves supercoils by nicking one DNA strand and facilitating religation after torsional stress has been relieved. During its reaction cycle, Top1 forms a covalent cleavage complex (Top1cc) with the nicked DNA, and this intermediate can be converted into a toxic double-strand...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6842612/ https://ncbi.nlm.nih.gov/pubmed/31636207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914081116 |
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