Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast

Topoisomerase II (Top2) is an essential enzyme that resolves catenanes between sister chromatids as well as supercoils associated with the over- or under-winding of duplex DNA. Top2 alters DNA topology by making a double-strand break (DSB) in DNA and passing an intact duplex through the break. Each...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Stantial, Nicole, Rogojina, Anna, Gilbertson, Matthew, Sun, Yilun, Miles, Hannah, Shaltz, Samantha, Berger, James, Nitiss, Karin C., Jinks-Robertson, Sue, Nitiss, John L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604471/
https://ncbi.nlm.nih.gov/pubmed/33046655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008721117
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