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Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast
Topoisomerase II (Top2) is an essential enzyme that resolves catenanes between sister chromatids as well as supercoils associated with the over- or under-winding of duplex DNA. Top2 alters DNA topology by making a double-strand break (DSB) in DNA and passing an intact duplex through the break. Each...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7604471/ https://ncbi.nlm.nih.gov/pubmed/33046655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008721117 |
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