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Frameshift Mutagenesis: The Roles of Primer–Template Misalignment and the Nonhomologous End-Joining Pathway in Saccharomyces cerevisiae

Small insertions or deletions that alter the reading frame of a gene typically occur in simple repeats such as mononucleotide runs and are thought to reflect spontaneous primer–template misalignment during DNA replication. The resulting extrahelical repeat is efficiently recognized by the mismatch r...

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Detalles Bibliográficos
Main Authors: Lehner, Kevin, Mudrak, Sarah V., Minesinger, Brenda K., Jinks-Robertson, Sue
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276632/
https://ncbi.nlm.nih.gov/pubmed/22095081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.134890
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