Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo

Ribonucleotides are the most abundant non-canonical component of yeast genomic DNA and their persistence is associated with a distinctive mutation signature characterized by deletion of a single repeat unit from a short tandem repeat. These deletion events are dependent on DNA topoisomerase I (Top1)...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Cho, Jang-Eun, Huang, Shar-yin N., Burgers, Peter M., Shuman, Stewart, Pommier, Yves, Jinks-Robertson, Sue
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027487/
https://ncbi.nlm.nih.gov/pubmed/27257064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw495
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items