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Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae
Topoisomerase I (Top1) removes DNA torsional stress by nicking and resealing one strand of DNA, and is essential in higher eukaryotes. The enzyme is frequently overproduced in tumors and is the sole target of the chemotherapeutic drug camptothecin (CPT) and its clinical derivatives. CPT stabilizes t...
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| Publicado no: | DNA Repair (Amst) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5691608/ https://ncbi.nlm.nih.gov/pubmed/28961461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.09.004 |
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