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Ribonucleotides and transcription-associated mutagenesis in yeast
High levels of transcription stimulate mutation rates in microorganisms and this occurs primarily through an enhanced accumulation of DNA damage. The major source of transcription-associated damage in yeast is topoisomerase I (Top1), an enzyme that removes torsional stress that accumulates when DNA...
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| Veröffentlicht in: | J Mol Biol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5296399/ https://ncbi.nlm.nih.gov/pubmed/27511624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.08.005 |
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