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Ribonucleotides and transcription-associated mutagenesis in yeast

High levels of transcription stimulate mutation rates in microorganisms and this occurs primarily through an enhanced accumulation of DNA damage. The major source of transcription-associated damage in yeast is topoisomerase I (Top1), an enzyme that removes torsional stress that accumulates when DNA...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Cho, Jang-Eun, Jinks-Robertson, Sue
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296399/
https://ncbi.nlm.nih.gov/pubmed/27511624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.08.005
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