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Two distinct mechanisms of Topoisomerase 1-dependent mutagenesis in yeast

Topoisomerase 1 (Top1) resolves transcription-associated supercoils by generating transient single-strand breaks in DNA. Top1 activity in yeast is a major source of transcription-associated mutagenesis, generating a distinctive mutation signature characterized by deletions in short, tandem repeats....

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Detalhes bibliográficos
Main Authors: Cho, Jang-Eun, Kim, Nayun, Li, Yue C., Jinks-Robertson, Sue
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594648/
https://ncbi.nlm.nih.gov/pubmed/23305949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.12.004
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