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Two distinct mechanisms of Topoisomerase 1-dependent mutagenesis in yeast
Topoisomerase 1 (Top1) resolves transcription-associated supercoils by generating transient single-strand breaks in DNA. Top1 activity in yeast is a major source of transcription-associated mutagenesis, generating a distinctive mutation signature characterized by deletions in short, tandem repeats....
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594648/ https://ncbi.nlm.nih.gov/pubmed/23305949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.12.004 |
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