Cohesin members Stag1 and Stag2 display distinct roles in chromatin accessibility and topological control of HSC self-renewal and differentiation

Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show Stag2 deletion in hematopoietic 5 stem/progenitor cells (HSPC) results in altered hematopo...

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Pubblicato in:Cell Stem Cell
Autori principali: Viny, Aaron D., Bowman, Robert L., Liu, Yu, Lavallée, Vincent-Philippe, Eisman, Shira E., Xiao, Wenbin, Durham, Benjamin H., Navitski, Anastasia, Park, Jane, Braunstein, Stephanie, Alija, Besmira, Karzai, Abdul, Csete, Isabelle S., Witkin, Matthew, Azizi, Elham, Baslan, Timour, Ott, Christopher J., Pe’er, Dana, Dekker, Job, Koche, Richard, Levine, Ross L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842438/
https://ncbi.nlm.nih.gov/pubmed/31495782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.08.003
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