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Iridium-Catalyzed, β-Selective C(sp(3))-H Silylation of Aliphatic Amines To Form Silapyrrolidines and 1,2-Amino Alcohols

The functionalization of unactivated C(sp(3))-H bonds of aliphatic amines catalyzed by transition-metal complexes is important because amine-based functionality is present in a majority of biologically active molecules and commercial pharmaceuticals. However, such reactions are underdeveloped and ch...

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Bibliographische Detailangaben
Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Su, Bo, Lee, Taegyo, Hartwig, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839912/
https://ncbi.nlm.nih.gov/pubmed/30354144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b10428
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