Structural analysis of free and liganded forms of the Fab fragment of a high-affinity anti-cocaine antibody, h2E2

A high-affinity anti-cocaine monoclonal antibody, designated h2E2, is entering phase 1 clinical trials for cocaine abuse therapy. To gain insight into the molecular details of its structure that are important for binding cocaine and cocaine metabolites, the Fab fragment was generated and crystallize...

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Vydáno v:Acta Crystallogr F Struct Biol Commun
Hlavní autoři: Tan, Kemin, Zhou, Min, Ahrendt, Angela J., Duke, Norma E. C., Tabaja, Nassif, Ball, William J., Kirley, Terence L., Norman, Andrew B., Joachimiak, Andrzej, Schiffer, Marianne, Wilton, Rosemarie, Pokkuluri, P. Raj
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2019
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839822/
https://ncbi.nlm.nih.gov/pubmed/31702583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19013608
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