Structural analysis of free and liganded forms of the Fab fragment of a high-affinity anti-cocaine antibody, h2E2

A high-affinity anti-cocaine monoclonal antibody, designated h2E2, is entering phase 1 clinical trials for cocaine abuse therapy. To gain insight into the molecular details of its structure that are important for binding cocaine and cocaine metabolites, the Fab fragment was generated and crystallize...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Tan, Kemin, Zhou, Min, Ahrendt, Angela J., Duke, Norma E. C., Tabaja, Nassif, Ball, William J., Kirley, Terence L., Norman, Andrew B., Joachimiak, Andrzej, Schiffer, Marianne, Wilton, Rosemarie, Pokkuluri, P. Raj
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2019
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839822/
https://ncbi.nlm.nih.gov/pubmed/31702583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19013608
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