A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations

BACKGROUND: For children with cancer, the clinical integration of precision medicine to enable predictive biomarker–based therapeutic stratification is urgently needed. METHODS: We have developed a hybrid-capture next-generation sequencing (NGS) panel, specifically designed to detect genetic alterat...

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Gepubliceerd in:Eur J Cancer
Hoofdauteurs: George, Sally L., Izquierdo, Elisa, Campbell, James, Koutroumanidou, Eleni, Proszek, Paula, Jamal, Sabri, Hughes, Deborah, Yuan, Lina, Marshall, Lynley V., Carceller, Fernando, Chisholm, Julia C., Vaidya, Sucheta, Mandeville, Henry, Angelini, Paola, Wasti, Ajla, Bexelius, Tomas, Thway, Khin, Gatz, Susanne A., Clarke, Matthew, Al-Lazikani, Bissan, Barone, Giuseppe, Anderson, John, Tweddle, Deborah A., Gonzalez, David, Walker, Brian A., Barton, Jack, Depani, Sarita, Eze, Jessica, Ahmed, Saira W., Moreno, Lucas, Pearson, Andrew, Shipley, Janet, Jones, Chris, Hargrave, Darren, Jacques, Thomas S., Hubank, Michael, Chesler, Louis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier Science Ltd 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839402/
https://ncbi.nlm.nih.gov/pubmed/31543384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2019.07.027
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