Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is the most intractable cancer in women with a high risk of metastasis. While hyper-methylation of histone H3 catalyzed by disruptor of telomeric silencing 1-like (DOT1L), a specific methyltransferase for histone H3 at lysine residue 79 (H3K79), is reported as a...

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Pubblicato in:Mol Ther Oncolytics
Autori principali: Byun, Woong Sub, Kim, Won Kyung, Han, Hae Ju, Chung, Hwa-Jin, Jang, Kyungkuk, Kim, Han Sun, Kim, Sunghwa, Kim, Donghwa, Bae, Eun Seo, Park, Sunghyouk, Lee, Jeeyeon, Park, Hyeung-geun, Lee, Sang Kook
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838941/
https://ncbi.nlm.nih.gov/pubmed/31720371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.09.005
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