Inhibition of DOT1L by Half-Selenopsammaplin A Analogs Suppresses Tumor Growth and EMT-Mediated Metastasis in Triple-Negative Breast Cancer

Due to a lack of hormone receptors, current treatment strategies for triple-negative breast cancer (TNBC) are limited with frequent disease recurrence and metastasis. Recent findings have suggested that aberrant methylation of histone H3 lysine 79 residue (H3K79me) by the histone methyltransferase d...

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Detalles Bibliográficos
Publicado en:Pharmaceuticals (Basel)
Main Authors: Byun, Woong Sub, Lee, Gyu Ho, Park, Hyeung-geun, Lee, Sang Kook
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7824081/
https://ncbi.nlm.nih.gov/pubmed/33379275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14010018
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