Antisense Oligonucleotide Inhibition of MicroRNA-494 Halts Atherosclerotic Plaque Progression and Promotes Plaque Stabilization

We have previously shown that third-generation antisense (3GA) inhibition of 14q32 microRNA (miRNA)-494 reduced early development of atherosclerosis. However, patients at risk of atherosclerotic complications generally present with advanced and unstable lesions. Here, we administered 3GAs against 14...

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Publicado en:Mol Ther Nucleic Acids
Main Authors: van Ingen, Eva, Foks, Amanda C., Kröner, Mara J., Kuiper, Johan, Quax, Paul H.A., Bot, Ilze, Nossent, Anne Yaël
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838792/
https://ncbi.nlm.nih.gov/pubmed/31689618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.09.021
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