In vivo CRISPR screening in CD8 T cells with AAV-Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma

Identification of T cell targets to improve immunotherapies is of prime interest. To facilitate large-scale CRISPR screens directly in T cells in vivo, here, we developed a hybrid genetic screening system with adeno associated virus (AAV) and the Sleeping Beauty (SB) transposon, where the transposon...

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Publicat a:Nat Biotechnol
Autors principals: Ye, Lupeng, Park, Jonathan J., Dong, Matthew B., Yang, Quanjun, Chow, Ryan D., Peng, Lei, Du, Yaying, Guo, Jianjian, Dai, Xiaoyun, Wang, Guangchuan, Errami, Youssef, Chen, Sidi
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834896/
https://ncbi.nlm.nih.gov/pubmed/31548728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0246-4
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