Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening

Cancer genomics consortia have charted the landscapes of numerous human cancers. Whereas some mutations were found in classical oncogenes and tumor suppressors, others have not yet been functionally studied in vivo. To date, a comprehensive assessment of how these genes influence oncogenesis is lack...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Wang, Guangchuan, Chow, Ryan D., Ye, Lupeng, Guzman, Christopher D., Dai, Xiaoyun, Dong, Matthew B., Zhang, Feng, Sharp, Phillip A., Platt, Randall J., Chen, Sidi
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829971/
https://ncbi.nlm.nih.gov/pubmed/29503867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aao5508
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