Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells

CD8 T cells play essential roles in anti-tumor immune responses. Here, we performed genome-scale CRISPR screens in CD8 T cells directly under cancer immunotherapy settings, and identified regulators of tumor infiltration and degranulation. The in vivo screen robustly re-identified canonical immunoth...

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Publicado no:Cell
Main Authors: Dong, Matthew B., Wang, Guangchuan, Chow, Ryan D., Ye, Lupeng, Zhu, Lvyun, Dai, Xiaoyun, Park, Jonathan J., Kim, Hyunu R., Errami, Youssef, Guzman, Christopher D., Zhou, Xiaoyu, Chen, Krista, Renauer, Paul A., Du, Yaying, Shen, Johanna, Lam, Stanley, Zhou, Jerry, Lannin, Donald R., Herbst, Roy S., Chen, Sidi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719679/
https://ncbi.nlm.nih.gov/pubmed/31442407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.07.044
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