Synergistic cancer immunotherapy combines MVA-CD40L induced innate and adaptive immunity with tumor targeting antibodies

Virus-based vaccines and appropriate costimulation potently enhance antigen-specific T cell immunity against cancer. Here we report the use of recombinant modified vaccinia virus Ankara (rMVA) encoding costimulatory CD40L against solid tumors. Therapeutic treatment with rMVA-CD40L-expressing tumor-a...

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Pubblicato in:Nat Commun
Autori principali: Medina-Echeverz, José, Hinterberger, Maria, Testori, Marco, Geiger, Marlene, Giessel, Raphael, Bathke, Barbara, Kassub, Ronny, Gräbnitz, Fabienne, Fiore, Giovanna, Wennier, Sonia T., Chaplin, Paul, Suter, Mark, Hochrein, Hubertus, Lauterbach, Henning
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834557/
https://ncbi.nlm.nih.gov/pubmed/31695037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12998-6
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