Intratumoral virotherapy with 4-1BBL armed modified vaccinia Ankara eradicates solid tumors and promotes protective immune memory

Background Human cancers are extraordinarily heterogeneous in terms of tumor antigen expression, immune infiltration and composition. A common feature, however, is the host′s inability to mount potent immune responses that prevent tumor growth effectively. Often, naturally primed CD8(+) T cells agai...

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Bibliografische gegevens
Gepubliceerd in:J Immunother Cancer
Hoofdauteurs: Hinterberger, Maria, Giessel, Raphael, Fiore, Giovanna, Graebnitz, Fabienne, Bathke, Barbara, Wennier, Sonia, Chaplin, Paul, Melero, Ignacio, Suter, Mark, Lauterbach, Henning, Berraondo, Pedro, Hochrein, Hubertus, Medina-Echeverz, José
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMJ Publishing Group 2021
Onderwerpen:
Oncolytic and Local Immunotherapy
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883866/
https://ncbi.nlm.nih.gov/pubmed/33579736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001586
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