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Facile Modifications at the C4 Position of Pyrimidine Nucleosides via In Situ Amide Activation with 1H-Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium Hexafluorophosphate
Two approaches for C4 modifications of silyl-protected thymidine, 2′-deoxyuridine, and 3′-azido-2′,3′-dideoxythymidine (AZT) are described. In both, nucleoside amide activation with 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and DBU yields O(4)-(benzotriazol-1-y...
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| I publikationen: | Curr Protoc Nucleic Acid Chem |
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| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6834435/ https://ncbi.nlm.nih.gov/pubmed/30688408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpnc.73 |
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