Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products()

Reactions of O-t-butyldimethylsilyl-protected thymidine, 2′-deoxyuridine, and 3′-azidothymidine (AZT) with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) leads to activation of the C4 amide carbonyl by formation of putative O(4)-(benzotriazolyl) derivatives. Subsequen...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Akula, Hari K., Kokatla, Hariprasad, Andrei, Graciela, Snoeck, Robert, Schols, Dominique, Balzarini, Jan, Yang, Lijia, Lakshman, Mahesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367150/
https://ncbi.nlm.nih.gov/pubmed/28054092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob02334g
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