Efficient cleavage resolves PAM preferences of CRISPR-Cas in human cells

Clustered regularly interspaced short palindromic repeats and associated proteins (CRISPR-Cas) of bacterial adaptive immunity have been adopted as a powerful and versatile tool for manipulation of the genome. This paradigm has been widely applied in biological research and treatments of animal or ce...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Regen
Hauptverfasser: Tang, Lianchao, Yang, Fayu, He, Xiaoxue, Xie, Haihua, Liu, Xiaoyu, Fu, Junhao, Xi, Haitao, Lu, Xiaosheng, Liu, Changbao, Song, Zongming, Qu, Jia, Zhao, Junzhao, Gu, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Chinese Society for Cell Biology 2019
Schlagworte:
Original Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833347/
https://ncbi.nlm.nih.gov/pubmed/31709036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cr.2019.08.002
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