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Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells
CRISPR/Cas9 -mediated DNA cleavage (CCMDC) is becoming increasingly used for efficient genome engineering. Proto-spacer adjacent motif (PAM) adjacent to target sequence is one of the key components in the design of CCMDC strategies. It has been reported that NAG sequences are the predominant non-can...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4066725/ https://ncbi.nlm.nih.gov/pubmed/24956376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05405 |
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