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PAM-dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease
C2c1 is a newly-identified guide RNA-mediated type V-B CRISPR-Cas endonuclease that site-specifically targets and cleaves both strands of target DNA. We have determined crystal structures of Alicyclobacillus acidoterrestris C2c1 (AacC2c1) bound to sgRNA as a binary complex and to target DNAs as tern...
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| Publicado no: | Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5278635/ https://ncbi.nlm.nih.gov/pubmed/27984729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.11.053 |
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