Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis

Here, the regulatory role of autophagy is examined in both an LPS-induced lethal endotoxic shock mouse model and cecal ligation and puncture (CLP) mouse model. Autophagy-inhibitor 3-methyladenine (3-MA) and autophagy-enhancer rapamycin were administrated to mice challenged with LPS or CLP. Animals c...

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Publicat a:Innate Immun
Autors principals: Li, Qirui, Li, Lingyun, Fei, Xiaoyuan, Zhang, Yuanyue, Qi, Chang, Hua, Shuyao, Gong, Feili, Fang, Min
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2018
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830927/
https://ncbi.nlm.nih.gov/pubmed/29673286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425918771170
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