Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis

BACKGROUND AND PURPOSE: Thrombopoietin (TPO), a growth factor primarily involved in thrombopoiesis may also have a role in the pathophysiology of sepsis. In patients with sepsis, indeed, TPO levels are markedly increased, with disease severity being the major independent determinant of TPO concentra...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Cuccurullo, Alessandra, Greco, Elisabetta, Lupia, Enrico, De Giuli, Paolo, Bosco, Ornella, Martin-Conte, Erica, Spatola, Tiziana, Turco, Emilia, Montrucchio, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786277/
https://ncbi.nlm.nih.gov/pubmed/26963510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151088
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