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Androgen Receptor Interaction with Mediator Complex is Enhanced in Castration-Resistant Prostate Cancer by CDK7 Phosphorylation of MED1
In this issue of Cancer Discovery, Rasool et al show that TF11H/CDK7 phosphorylates the MED1 component of the Mediator complex, which enhances its interaction with androgen receptor (AR), and that this phosphorylation is increased in prostate cancer (PCa) that is resistant to castration and enzaluta...
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| Vydáno v: | Cancer Discov |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6830511/ https://ncbi.nlm.nih.gov/pubmed/31676563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1028 |
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