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LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

Deficiency of the LIS1 protein causes lissencephaly, a brain developmental disorder. Although LIS1 binds the microtubule motor cytoplasmic dynein and has been linked to dynein function in many experimental systems, its mechanism of action remains unclear. Here, we revealed its function in cargo-adap...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Biol
Egile Nagusiak: Qiu, Rongde, Zhang, Jun, Xiang, Xin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829669/
https://ncbi.nlm.nih.gov/pubmed/31562232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201905178
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