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LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

Deficiency of the LIS1 protein causes lissencephaly, a brain developmental disorder. Although LIS1 binds the microtubule motor cytoplasmic dynein and has been linked to dynein function in many experimental systems, its mechanism of action remains unclear. Here, we revealed its function in cargo-adap...

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書目詳細資料
發表在:J Cell Biol
Main Authors: Qiu, Rongde, Zhang, Jun, Xiang, Xin
格式: Artigo
語言:Inglês
出版: Rockefeller University Press 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829669/
https://ncbi.nlm.nih.gov/pubmed/31562232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201905178
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