Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

Chronic activation of brain innate immunity is a prominent feature of Alzheimer’s disease (AD) and primary tauopathies. However, to what degree innate immunity contributes to neurodegeneration as compared with pathological protein-induced neurotoxicity, and the requirement of a particular glial cell...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Shi, Yang, Manis, Melissa, Long, Justin, Wang, Kairuo, Sullivan, Patrick M., Remolina Serrano, Javier, Hoyle, Rosa, Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829593/
https://ncbi.nlm.nih.gov/pubmed/31601677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190980
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