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Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning
Despite the importance of Aβ aggregation in Alzheimer’s disease etiology, our understanding of the sequence determinants of aggregation is sparse and largely derived from in vitro studies. For example, in vitro proline and alanine scanning mutagenesis of Aβ(40) proposed core regions important for ag...
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| 出版年: | G3 (Bethesda) |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Genetics Society of America
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6829127/ https://ncbi.nlm.nih.gov/pubmed/31558564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.119.400535 |
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