Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with dementia severity when compared with other pathological features of the diseas...

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Publicado no:Sci Rep
Main Authors: Forner, Stefania, Martini, Alessandra C., Prieto, G. Aleph, Dang, Cindy T., Rodriguez-Ortiz, Carlos J., Reyes-Ruiz, Jorge Mauricio, Trujillo-Estrada, Laura, da Cunha, Celia, Andrews, Elizabeth J., Phan, Jimmy, Vu Ha, Jordan, Chang, Allissa V. Z. D., Levites, Yona, Cruz, Pedro E., Ager, Rahasson, Medeiros, Rodrigo, Kitazawa, Masashi, Glabe, Charles G., Cotman, Carl W., Golde, Todd, Baglietto-Vargas, David, LaFerla, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828807/
https://ncbi.nlm.nih.gov/pubmed/31685865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52324-0
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