Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with dementia severity when compared with other pathological features of the diseas...

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Publicat a:Sci Rep
Autors principals: Forner, Stefania, Martini, Alessandra C., Prieto, G. Aleph, Dang, Cindy T., Rodriguez-Ortiz, Carlos J., Reyes-Ruiz, Jorge Mauricio, Trujillo-Estrada, Laura, da Cunha, Celia, Andrews, Elizabeth J., Phan, Jimmy, Vu Ha, Jordan, Chang, Allissa V. Z. D., Levites, Yona, Cruz, Pedro E., Ager, Rahasson, Medeiros, Rodrigo, Kitazawa, Masashi, Glabe, Charles G., Cotman, Carl W., Golde, Todd, Baglietto-Vargas, David, LaFerla, Frank M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828807/
https://ncbi.nlm.nih.gov/pubmed/31685865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52324-0
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