Evaluation of the reactogenicity, adjuvanticity and antigenicity of LT(R192G) and LT(R192G/L211A) by intradermal immunization in mice

The development of an effective subunit vaccine is frequently complicated by the difficulty of eliciting protective immune responses, often requiring the co-administration of an adjuvant. Heat-labile toxin (LT), an enterotoxin expressed by enterotoxigenic E. coli (ETEC) with an AB(5) structure simil...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Maciel, Milton, Smith, Mark, Poole, Steven T., Laird, Renee M., Rollenhagen, Julianne E., Kaminski, Robert W., Wenzel, Heather, Bourgeois, A. Louis, Savarino, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827915/
https://ncbi.nlm.nih.gov/pubmed/31682624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224073
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