A Phase 1 Dose Escalating Study of Double Mutant Heat-Labile Toxin LTR192G/L211A (dmLT) from Enterotoxigenic Escherichia coli (ETEC) by Sublingual or Oral Immunization

BACKGROUND: The public health burden of Enterotoxigenic Escherichia coli (ETEC) is high but no vaccine is specifically approved to prevent ETEC infections. METHODS: We performed a Phase 1, dose escalation study (1 to 50 μg) evaluating the sublingual (SL) delivery of the double mutant heat-labile tox...

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Publicat a:Vaccine
Autors principals: Bernstein, David I., Pasetti, Marcela F., Brady, Rebecca, Buskirk, Amanda D., Wahid, Rezwanul, Dickey, Michelle, Cohen, Mitchell, Baughman, Holly, El-Khorazaty, Jill, Maier, Nicole, Sztein, Marcelo B., Baqar, Shahida, Bourgeois, A. Louis
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331259/
https://ncbi.nlm.nih.gov/pubmed/30563789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2018.12.011
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